“I haven’t pinpointed what I specifically want to work on, but I’m eager to do research that has some kind of positive impact on the world, whether that’s helping people or the environment,” Bonanni said. “I want my research to have a bigger purpose.”

Some student researchers focus on a single topic, but Bonanni has dabbled in several—and because of this, she sees the world differently, said a Fordham professor. 

“Her experience has given her a good view of different topics. She can ask questions that other people might not be thinking about,” said her academic advisor Patricio Meneses, Ph.D., associate professor of biological sciences. “This will benefit her when it comes to asking the next interesting or necessary question in science.” 

‘A Whole New World Opened Up’ 

Bonanni was born to a family of scientists in Niskayuna, New York. Her father is an electrical engineer at General Electric. Her mother, a longtime optometrist, pursued her career when there were few women in her field. Both inspired their daughter to become a researcher. 

Bonanni had always been fascinated by the natural world. In elementary school, she drew three-page pictures of different landscapes and the flora and fauna that lived within them. But in high school, Bonanni realized that science was more than a childhood interest. 

“When I took a biology course, it was like a whole new world opened up. I learned how the natural world works, how everything fits together in ecosystems, and how life functions. Once I knew that was a field, I was like, ‘Wow—that’s the one for me,’” she said. 

Growing as a Biologist at Fordham

In 2020, she enrolled at Fordham. She wanted to attend school in New York City, and she was drawn to Fordham’s Jesuit ideals.

“I knew that I could find a Catholic community at other colleges, but I liked how Fordham implements the Jesuit values in their course philosophy,” she said. 

Bonanni spent her first year on Zoom due to the pandemic. The following summer, she took two tuition-free classes. Among them was a genetics course with biology professor Edward Dubrovsky, Ph.D., whose work she loved so much that she asked if she could work in his lab. 

Throughout her sophomore year, they examined the genetic mutations responsible for cardiomyopathy, a disease that thickens heart tissue and can lead to death. Using fruit flies as a model for the human body, they explored a question: Where do the mutated genes that cause cardiomyopathy need to be located in order for symptoms to develop? Any cell in the body or specifically in the heart? (They later learned that the latter was correct.) 

Under Dubrovsky, Bonanni learned what it’s like to work in a real lab, versus a classroom. 

“When you’re in a research lab, you don’t know what the answer is. Sometimes things don’t go right the first time, but that’s just part of the research process,” Bonanni said. “That uncertainty is where discoveries are made.” 

The following summer, she studied in Australia through Fordham’s partnership with the School for Field Studies. For one month, she lived in the rainforest and conducted fieldwork on marsupials. 

“It was really cool to learn about how they came to be in Australia and set up field cameras to take pictures of marsupials passing by, like pademelons,” Bonanni said. 

Exploring Bronx Plant Life

She loved working with animals, but she also wanted to try working with plants. She had always enjoyed tending to her family’s vegetable garden, where they raised tomatoes, lettuce, squash, and beans. 

Last fall, she studied the spread of Japanese knotweed, an invasive species that has spread to the Bronx, in the lab of biology professor Steven J. Franks, Ph.D. She enjoyed the experience, but realized she preferred working with animal cells. 

Keeping the Earth Safe for Turtles

This semester, Bonanni started working on a project that combines her interests in cell and molecular biology and ecology. 

In the lab of Evon Hekkala, Ph.D., associate professor of biological sciences, Bonanni is studying green sea turtles, the largest hard-shelled sea turtle on Earth. Every year, these turtles return to the same beach to lay their eggs. The problem is only some areas are protected from poaching and other activities that prevent babies from hatching and safely making their way to the ocean. 

“If only specific areas are protected, then only specific turtle genes might be protected. That means you’re limiting the genetic diversity of the population,” Bonanni said. “A less genetically diverse population is less likely to survive diseases,” said Bonanni, who is now analyzing DNA from hatched turtle shells to assess their genetic diversity. 

The Wonder of the Natural World 

Bonanni wants to become a biologist. No matter what she focuses on, she says she wants to hold onto something that we often forget as adults—the wonder of the natural world. 

“Growing plants is so exciting when you really think about it,” said Bonanni, who once worked as a summer camp counselor who taught children how to water seeds into sunflowers. “The fact that a beautiful, green, lush thing can come out of a small seed is so cool. As adults, we sometimes lose the wonder associated with that. But when you look at a kid experiencing it for the first time, you remember how exciting it really is.”   

A recent report connecting the human ELAC2 gene to the occurrence of prostate cancer in men piqued Dubrovsky’s curiosity. In his Rose Hill lab, he and his students had cloned a Drosophila RNase Z gene, and done lengthy studies on its protein activity. They established that both the human ELAC2 gene and the Drosophila RNase Z gene shared certain structures and enzyme activities that classified them as “homolog” genes (one similar in structure and evolutionary origin to a gene in another species).

Now that it appeared the fruit fly’s RNase Z gene mirrored the activity of the human prostate cancer (PCA) susceptibility gene ELAC2, Dubrovsky saw a chance to study the human disease through the tiny winged insect.

This year his lab has received a grant from the Department of Health for New York State to undertake research to help influence and improve early diagnosis of the disease—PCA is the second-leading cause of cancer death in men in the United States.

“I’m not a doctor, I don’t meet patients. But I still believe that we can help improve [the disease’s] diagnostic. We are working toward further knowledge of the mechanisms underlying the initiation of PCA. Using a fly model, we can find mechanisms regulating prostate growth and development of PCA,” said Dubrovsky, professor of biology.

In his Rose Hill campus lab, where he houses hundreds of vials of fruit flies, Dubrovsky and graduate students are creating flies that have the same genetic mutation found in humans predisposed to the disease.  Dubrovsky says they do not yet know “how certain mutations can result in increased risk of PCA,” but his study offers two hypotheses: one involves an alteration of RNase Z enzymatic function that creates cancer cell growth; and another that looks at whether RNase Z could have  a completely different function unrelated to enzymatic activity, but that, when damaged, may lead to transformation of prostatic cells.

He hopes that studying the mutant flies will shed some light on the mystery of how the disease develops.

Although he says there are “other models closer to humans to study,” Dubrovsky sees an advantage with the fruit fly because of its short life cycle: the fruit flies undergo an approximate 10-day metamorphosis from egg to larva to pupa to flying insect, and then live for approximately another 2 months under optimal conditions.

“Because of the fly is so quick to live and die, we can create genetic lines that carry any desired mutation within short period of time” he said.

Dubrovsky began studying the fruit fly’s hormonal and genetic characteristics as a student in his home country of Russia. From there, he moved to France to continue his schooling and research, and eventually came to the United States, where he was a member of the faculty of Dartmouth College for 11 years.

In 2006, he came to Fordham, where his research into the genetic and hormonal activities of Drosophila continues.

“They still fascinate me,” he said.

Related Articles: Biologist Studies Genetics of Fruit Flies

WHO GAVE IT: The New York State Department of Health
WHO GOT IT: Edward Dubrovsky, PhD, professor of biology
HOW MUCH: $77,005
WHAT FOR: A grant to explore the role of mutations in a gene called ELAC2 in prostate cancer

Orthodox Christian Studies

WHO GAVE IT: The Carpenter Foundation combined with a Fordham Faculty Fellowship
WHO GOT IT: George Demacopoulos, PhD, the Fr. John Meyendorff & Patterson Family Chair of Orthodox Christian Studies
HOW MUCH: $30,000
WHAT FOR: A yearlong sabbatical for his project, “Colonizing Christianity: Prejudice and Sex in the Crusader East”

Art History

WHO GAVE IT: National Endowment for the Humanities
WHO GOT IT: Nina Rowe, PhD, associate professor of art history
HOW MUCH: $50,400
WHAT FOR: To complete a book on late medieval illuminated World Chronicle manuscripts

Arts and Sciences

WHO GAVE IT: Association of Catholic Colleges and Universities
WHO GOT IT: Eva Badowska, PhD, dean of the Graduate School of Arts and Sciences, and doctoral candidate in philosophy Joseph Vukov
HOW MUCH: $2,000
WHAT FOR: A grant to study how Fordham graduate students perceive their education in the context of the University’s mission

Graduate School of Education

WHO GAVE IT:  Marie Noelle Chynn, GSS ’60 and Kuo York Chynn, M.D
WHO GOT IT: Graduate School of Education
HOW MUCH: $104,000
WHAT FOR: Dr. J.T. Vincent Lou Memorial Endowed Fellowship

Irish Studies

WHO GAVE IT:  Mary Brautigam, TMC ’74, and Richard Brautigam, FCRH ’73
WHO GOT IT: Irish Studies
HOW MUCH: $6,000
WHAT FOR: Four Irish Cultural Events in the Spring of 2016

Engineers Without Borders

WHO GAVE IT:  Mary Jane McCartney, TMC’ 68 and George McCartney, FCRH ’68, LAW ’72
WHO GOT IT: Engineers Without Borders
HOW MUCH: $13,000 challenge grant
WHAT FOR: A challenge grant that raised $27,000 to support EWB’s trip to Uganda to build fish farms

Physics

WHO GAVE IT:  Christa and John Reddy, FCRH ’77
WHO GOT IT: Department of Physics and Engineering Physics
HOW MUCH: $10,000
WHAT FOR: Supplies for Experiments

Other major grant-winners last year included:

• Yilu Zhou, PhD, professor of information sciences, who received a National Science Foundation grant to research age recommendations on mobile apps;
• Winnie Kung, PhD, associate professor of social work, who received a grant from the Centers for Disease Control and Prevention to study the impact among Asian survivors and rescuers exposed to the World Trade Center attack; and
• Lise Schreier, PhD, associate professor of French, who won a National Endowment for the Humanities grant for her research on the 18th-century practice of “child-gifting.”