Christine Zolnik – Fordham Now https://now.fordham.edu The official news site for Fordham University. Tue, 11 Jun 2024 19:20:56 +0000 en-US hourly 1 https://now.fordham.edu/wp-content/uploads/2015/01/favicon.png Christine Zolnik – Fordham Now https://now.fordham.edu 32 32 232360065 Research Challenges Lyme Disease Hypothesis https://now.fordham.edu/science/research-challenges-lyme-disease-hypothesis/ Fri, 09 Oct 2015 14:00:00 +0000 http://news.fordham.sitecare.pro/?p=29117 The result of a new study at Fordham’s Calder Biological Field Station is challenging a traditionally accepted scientific hypothesis on biodiversity and Lyme disease.

The hypothesis, known as the “dilution effect”, says that disease pathogens are less frequent in areas with a greater number of host species.

“Some hosts are really bad at maintaining and transmitting the Lyme disease pathogen, and some are very good, what we call competent reservoirs,” said Christine Zolnik, PhD, a recent doctoral graduate and co-author of the study recently published in PLoS ONE. “The thinking is that the more species you have, then the more you’re able to dilute what we call the ‘competent reservoir.’”

Computer Simulation vs. Hard Numbers

Blacklegged ticks are known to transmit Lyme disease to a variety of animals. They have more than 100 potential host species, and in the past 10 to 15 years the Lyme/tick/host relationship has become an oft-cited example of the dilution effect.

Many of the studies on dilution effect are built on computer simulations with limited empirical data—i.e.—hard numbers from the real world, said Zolnik. But for her study, she chose to compare actual areas.

“Because there’s such large number of potential tick hosts at a site, it’s very difficult to assess biodiversity at each collection location,” she said. “Therefore, I used habitat fragmentation as a proxy for biodiversity.”

The area of less biodiversity was one with “landscape fragmentation,” meaning lots of buildings and streets interrupting nature. The area of more biodiversity consisted of woodlands that provide uninterrupted food and shelter for a variety of creatures.

The thinking was that pathogen prevalence within a blacklegged tick population would vary greatly between a fragmented landscape and a less-fragmented landscape.

Fragmented Bronx Landscapes vs. the Woods of Westchester

Zolnik collected tick samples at 14 sites across the Bronx, Westchester, and Putnam counties in New York, and in Litchfield County, Connecticut.

The Bronx sites were far more fragmented than the other sites, but, to Zolnik’s surprise, fragmentation didn’t affect the number of infected ticks found.

“I did find variation between the sites, but I didn’t find any evidence to the dilution effect,” she said. “So we still really don’t have a handle on what’s influencing the infection rate.”

“This study provides evidence that is not in support of a hypothesis that is taken as dogma in the Lyme disease field,” she said. “Just because something is accepted doesn’t always make it correct. But this opens the door for other studies.”

Zolnik said that there’s plenty more to be studied, such as the composition of the host community beyond the well-known dominant species and reservoirs. She said that this is just the type of work that’s ongoing at Fordham’s Vector Ecology Lab where she began her dissertation work with advisors Thomas J. Daniels, PhD, the director of the Calder Center and Sergios-Orestis Kolokotronis, PhD, of the Biological Sciences department. Daniels, Kolokotronis and Richard Falco, PhD, of the New York State Department of Health co-authored the study.

Zolnik said that she didn’t set out to prove or disprove the hypothesis in her dissertation.

“I wanted to find evidence that either supported the hypothesis or not,” she said. “There was a gap in the literature that needed to be filled.”

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Fordham Student Taps Mammals Large and Small for Tick Research https://now.fordham.edu/inside-fordham/fordham-student-taps-mammals-large-and-small-for-tick-research/ Thu, 08 Nov 2012 17:16:02 +0000 http://news.fordham.sitecare.pro/?p=6966 On the “Aww, aren’t they cute!” scale, bears, chipmunks, and mice would seem to inhabit the opposite ends of the spectrum.

Christine Zolnik with a sedated black bear in New Jersey. Contributed Photo
Christine Zolnik with a sedated black bear in New Jersey.
Contributed Photo

But from Christine Zolnik’s perspective, they’re on equal footing when it comes to understanding how tick-borne diseases spread through cities, suburbs and forests.

For her dissertation, Zolnik, a doctoral candidate in biology who works out of the Louis Calder Biological Field Station’s vector ecology lab, is looking at the effects of urbanization on populations of ticks and two of their most common hosts—white-footed mice and eastern chipmunks.

She spent this past summer trapping and taking DNA samples from them in locations ranging from the Bronx to Duchess County and Western Connecticut. During the summer of 2011, she collected ticks from the same locales. Once she has gathered enough samples, she plans to conduct genetic tests to compare the populations of ticks and their hosts at the sites.

The questions she wants to answer are, how closely do tick populations correlate with mice and chipmunks, which are their common hosts? And how do human landscape changes such as urbanization influence the populations of these small mammals and the parasites and diseases they carry?

“We know that other animals can harbor these ticks and move them, but we’re not really sure how important mice and chipmunks are at maintaining the population and moving them around,” she said.

“If the ticks match the chipmunks and mice, then it’s pretty good evidence that even though birds and deer are important carriers, they’re not as important for dispersal.”

Zolnik takes a tissue sampling from a white-footed mouse before letting it go.  Contributed Photo
Zolnik takes a tissue sampling from a white-footed mouse before letting it go.
Contributed Photo

Black bears, on the other hand, are not actively roaming the woods of Westchester, but they can be found in rural New Jersey, where the New Jersey Fish and Wildlife Service actively monitors them. Since the only studies of bears as carriers of tick-borne diseases have been done in places like Georgia and Florida, Zolnick figured bears were worthy of study too.

“I was able to tag along and participate in the services’ research trapping in June and September to do a census of the parasites on the bears’ bodies, and to get a real sense of the parasites on them, in an area where bears are becoming more prevalent and where ticks and tick-borne diseases are prevalent,” she said. “I took some blood to test for tick-borne pathogens as well.”

Zolnik said the idea is to get a better feel for the complex relationship between ticks, their hosts, and the diseases they carry. Mice and chipmunks are abundant and close to the ground, which makes them easier for immature-stage ticks to latch on to. But unlike bears and deer, they don’t travel very far.

Variations also exist within animals that exhibit similar behaviors and have similar body types; for example, raccoons make for good hosts while opossums do not.

“To add complexity to it, some hosts are very good at maintaining the pathogens that the ticks transmit, while others are not. White-footed mice, in particular, are very good at maintaining pathogens, whereas white-tailed deer are considered a dead-end host,” Zolnik said.

“Even if deer get infected with Lyme, they won’t transmit it to another tick. It’s the same with people. We can get Lyme, but we clear it out of our blood so fast, that if another tick were to feed on us, we wouldn’t infect that tick.”

So who makes for a better ride for ticks looking to expand their range? A big animal that’s harder to reach but travels great distances? Or a small one that is more accessible but is limited in how far it can travel?

Zolnik hopes to shed some light on this question. Last month, she presented a portion of her research involving the genetic differentiation and disease prevalence of blacklegged ticks along an urban-rural gradient at the Fourth Biennial Conference of the International Association for Ecology and Health, Kunming City, China and the Third International Conference of Urban Biodiversity and Design, Mumbai, India.

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Fordham Student Taps Mammals Large and Small for Tick Research https://now.fordham.edu/university-news/fordham-student-taps-mammals-large-and-small-for-tick-research-2/ Thu, 08 Nov 2012 19:45:28 +0000 http://news.fordham.sitecare.pro/?p=30457 bears1On the “Aww, aren’t they cute!” scale, bears, chipmunks, and mice would seem to inhabit the opposite
ends of the spectrum.

But from Christine Zolnik’s perspective, they’re on equal footing when it comes to understanding how tick-borne diseases spread through cities, suburbs and forests.

For her dissertation, Zolnik, a doctoral candidate in biology who works out of the Louis Calder Biological Field Station’s vector ecology lab, is looking at the effects of urbanization on populations of ticks and two of their most common hosts—white-footed mice and eastern chipmunks.

She spent this past summer trapping and taking DNA samples from them in locations ranging from the Bronx to Duchess County and Western Connecticut. During the summer of 2011, she collected ticks from the same locales. Once she has gathered enough samples, she plans to conduct genetic tests to compare the populations of ticks and their hosts at the sites.

The questions she wants to answer are, how closely do tick populations correlate with mice and chipmunks, which are their common hosts? And how do human landscape changes such as urbanization influence the populations of these small mammals and the parasites and diseases they carry?

“We know that other animals can harbor these ticks and move them, but we’re not really sure how important mice and chipmunks are at maintaining the population and moving them around,” she said.

“If the ticks match the chipmunks and mice, then it’s pretty good evidence that even though birds and deer are important carriers, they’re not as important for dispersal.”

Black bears, on the other hand, are not actively roaming the woods of Westchester, but they can be found in rural New Jersey, where the New Jersey Fish and Wildlife Service actively monitors them. Since the only studies of bears as carriers of tick-borne diseases have been done in places like Georgia and Florida, Zolnick figured bears were worthy of study too.

“I was able to tag along and participate in the services’ research trapping in June and September to do a census of the parasites on the bears’ bodies, and to get a real sense of the parasites on them, in an area where bears are becoming more prevalent and where ticks and tick-borne diseases are prevalent,” she said. “I took some blood to test for tick-borne pathogens as well.”

Zolnik said the idea is to get a better feel for the complex relationship between ticks, their hosts, and the diseases they carry. Mice and chipmunks are abundant and close to the ground, which makes them easier for immature-stage ticks to latch on to. But unlike bears and deer, they don’t travel very far.

Variations also exist within animals that exhibit similar behaviors and have similar body types; for example, raccoons make for good hosts while opossums do not.

“To add complexity to it, some hosts are very good at maintaining the pathogens that the ticks transmit, while others are not. White-footed mice, in particular, are very good at maintaining pathogens, whereas white-tailed deer are considered a dead-end host,” Zolnik said.

“Even if deer get infected with Lyme, they won’t transmit it to another tick. It’s the same with people. We can get Lyme, but we clear it out of our blood so fast, that if another tick were to feed on us, we wouldn’t infect that tick.”

So who makes for a better ride for ticks looking to expand their range? A big animal that’s harder to reach but travels great distances? Or a small one that is more accessible but is limited in how far it can travel?

Zolnik hopes to shed some light on this question. Last month, she presented a portion of her research involving the genetic differentiation and disease prevalence of blacklegged ticks along an urban-rural gradient at the Fourth Biennial Conference of the International Association for Ecology and Health, Kunming City, China and the Third International Conference of Urban Biodiversity and Design, Mumbai, India.

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